Relative risk of CHD by TG (1)

Objective: To examine evidence from the Framingham Heart Study as it relates to elevated triglycerides and risk for CHD.

General summary: The Framingham Heart Study was started in 1948. A mostly random sample of 5,209 respondents was selected from the 10,000 men and women in Framingham who were aged 30-60 years. Of the random sample, 5,127 were free of clinically overt disease at entry and formed the prospective cohort.

• In the univariate analysis, the Framingham heart Study found a simple linear relation between serum triglycerides and the subsequent development of CAD. This was statistically significant in all correlations in women but only in the 30-year data among the men.
• Relative risk of coronary artery disease (CHD) by serum triglyceride (sf 20-400) levels in men and women (30-year follow-up).
  
  The independent effect of raising HDL-C or lowering TG on the risk of cardiovascular morbidity and mortality has not been determined. (2)

Framingham Heart Study: Relationship of HDL-C, LDL-C and risk for CHD

Risk of CHD by HDL-C vs LDL-C (3)

Objective: To examine the use of blood lipids in predicting CAD with the aim of determining people who may need lowering of blood lipids by diet or drugs.

General summary: The Framingham Heart Study was started in 1948. A mostly random sample of 5,209 respondents was selected from the 10,000 men and women in Framingham who were aged 30-60 years. Of the random sample, 5,127 were free of clinically overt disease at entry and formed the prospective cohort.

• The Framingham Heart Study showed that an LDL cholesterol level of 100 mg/dL with an HDL cholesterol of 25 mg/dL had the same risk for CAD as an LDL cholesterol level of 220 mg/dL with an HDL cholesterol of 45 mg/dL.
• Risk of CAD in men aged 50 to 70 years according to HDL-C and LDL-C over 4 years of follow-up in the Framingham Heart Study.
  
  The independent effect of raising HDL-C or lowering TG on the risk of cardiovascular morbidity and mortality has not been determined (2).